Have you come across JAK treatment failure in severe alopecia areata?

I’ve considered Dupilumab, but first try to switch the JAK inhibitor, add minoxidil if not already on it, and add some type of steroid, less often systemic.

Unfortunately, each individual JAK inhibitor doesn't lead to full regrowth in everyone. I agree with Dr. @Dr. First Last, I consider switching JAK inhibitors or starting Dupilumab, as well as increasing the dose of minoxidil.

New JAK inhibitors may work better and some have fewer side effects.