Have you seen rheumatoid nodules or RA-ILD in patients with seronegative RA?

By definition, rheumatoid nodules are considered to be a highly specific manifestation of RA. Regarding the first part of the question, one should never see true rheumatoid nodules in someone who does not have seronegative RA. Though there are sporadic case reports of finding these nodules in people...

I have a few patients with subcutaneous RA nodules who have seronegative RA. I often repeat the serologies because as stated above, you would expect these patients to be seropositive. If the patient is a smoker, this facilitates nodule formation. I believe ILD or "RA lung" in true seronegative RA is...