In your practice, what premedications do you use for subcutaneous daratumumab?

We administer the following pre-infusion medications 1 hour to 3 hours before the first 4 SQ infusions, and then we drop all premedications (except for dexamethasone) thereafter:

• Dexamethasone 20-40 mg
• Acetaminophen 650 mg
• Diphenhydramine 25 mg
• Montelukast 10 mg [this is not in the package insert b...

I agree 99.9% with @Dr. First Last's excellent answer, with the exception of how long the dexamethasone is truly required; nothing new since we've discussed this before via Twitter. His group has published on their experience (see my comment on his answer), which has been very helpful here!

As a rati...