Have you utilized denosumab in treatment of erosive hand osteoarthritis?

I have not prescribed denosumab for patients with erosive hand osteoarthritis. While the 2024 double-blind placebo-controlled trial suggested that this RANK ligand inhibitor may have structure-modifying effects by inducing remodeling and preventing new erosions, the phase 2a study of 100 patients di...

No, I have not incorporated denosumab into my routine practice for erosive hand osteoarthritis.

I found the Nature Medicine study (Wittoek et al., PMID 38361122) to be very interesting and well conducted, with convincing biological rationale and encouraging structural signals. However, at this stage,...

I agree. My concern is also the fracture risk. However, there is another issue. What is referred to as erosive osteoarthritis actually appears to be calcium pyrophosphate deposition disease, and hydroxychloroquine appears an effective treatment.