How are you making the diagnosis of chronic lymphocytic leukemia transforming to prolymphocytic leukemia?

Looking at the trend of pro-lymphocyte increase will help in addition to clinical signs of progressive disease (splenomegaly). It is useful to check for TP53 and MYC translocations since these are common in PLL.

As you mentioned, >55% pro-lymphocytes has been used to diagnosed PLL based on a report ...