How are you sequencing immunotherapy with zolbetuximab in locally advanced/metastatic GEJ cancer when CPS >5 and Claudin 18.2+ (>75%)?
With first line approvals in both FOLFOX/Nivo and FOLFOX/zolbetuximab, how are you sequencing treatment if both CPS/Claudin markers are adequate to treat with either therapy, barring no contraindication to either treatment?
Community PollStarted
How are you sequencing immunotherapy with zolbetuximab in locally advanced/metastatic GEJ cancer when CPS >5 and Claudin 18.2+ (>75%)?
28 physicians have voted
Join Mednetto vote and see how they answered.
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Mayo Clinic
Answered on
In Claudin+:
CPS 5 and above, would do checkpoint+ chemo
CPS less than 5, would do chemo +zolbe.
There is an ongoing study that will answer the question of the quadrable therapy. Till then, would do as the above given that CPI can give us OS benefit, and also ORR benefit, which was not very impressi...
Join for free or sign in to see the full answer