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How are you treating MSI-H CRC in a liver transplant recipient on tacrolimus & sirolimus?
History of OLT (3 years ago), no response to pembro mono tx after 2 mo. Too immunosuppressed?
Answer from: Medical Oncologist at Academic Institution
This is an important question; however, our experience in the metastatic colorectal cancer (mCRC) setting remains very limited. This patient underwent liver transplantation three years ago and has since developed dMMR/MSI-H metastatic colorectal cancer. The patient is currently receiving tacrolimus ...
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Answer from: Medical Oncologist at Community Practice
For patients with dMMR/MSI-H metastatic colorectal cancer who have progressed on checkpoint inhibitor (ICI) monotherapy, combination PD-1/CTLA-4 blockade with nivolumab plus ipilimumab is recommended. However, immune checkpoint inhibitors carry a high risk of allograft rejection in solid organ trans...