How do PSMA PET positive nodes change your treatment recommendations after RP?

I would incorporate PSMA avid regional node findings into salvage treatment planning with regard to guiding a) nodal basin coverage extending to give buffer on most cranial node or at least to the aortic bifurcation given PSMA-LND correlate studies often showing more involved adjacent basin disease ...

The answer is, definitely. Recently published multi variant analysis in JCO by Tilki et al., PMID 35290082 looking at adjuvant vs salvage radiation in post RP setting based on the number of positive LN found there to be roughly 8% reduction in the risk of 7 year all cause mortality per positive LN. ...