How do you account for tumor growth from pre-operative to intra-operative ultrasound for uveal melanoma?

On B scan, measure the thickness from apex AP and also do basal measurements. Base measurements are done through indirect ophthalmoscope also. At each visit, pre-op and postop, both B scan measurements (for tumor thickness) are done and also indirect ophthalmoscope measurements. My twin sister is an ocular oncologist. She uses 2 mm margin at Wills eye. They don't add any time as plaque is placed within 2-3 days of seeing a patient in clinic. They don't do less dose at apex. Maximum dose is at the apex even if it is juxtapapillary location. Very rarely, there is necrosis within ch mm and they regress faster without treatment. Still in those cases, they give full dose to apex. There are risk factors to assess at first visit. Based on those ri...

PDT: photodynamic therapy for amelanotic melanoma.

Intravitreal chemotherapy is under investigation and also intra-arterial chemotherapy (not yet standard of care)