How do you approach a patient with an anaplastic plasmacytoma without systemic evidence of disease in the bone marrow?

Topics: Hematologic Malignancies • Medical Oncology • Myeloma • NCI-CCC Tumor Board Question • University of Chicago • NCI-CCC Myeloma Tumor Board Question

What about multiple anaplastic plasmacytoma without bone marrow involvement?

Answer from: Medical Oncologist at Community Practice

I'm not sure what an anaplastic plasmacytoma is. Is it a plasmacytoma that is made up of amorphous cells that express CD138, are clonal, and don't express EBER, ALK, or HHV8? This seems to follow along the lines of what is a plasmablastic neoplasm. If there are no clonal plasma cells in the ma...

Comments

Medical Oncologist at University of Chicago
Anaplastic plasmacytomas, or sometimes referred to...

Medical Oncologist at UW Madison
See also this question for some additional discuss...

Answer from: Medical Oncologist at Academic Institution

Agreed with @Craig C. Hofmeister on all fronts above. I'll specifically touch on the follow-up question (multiple biopsy-proven anaplastic plasmacytomas but BM neg). My vote, in that case, would be to repeat the bone marrow, since I'd argue that the chances of this scenario truly unfolding are...

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