How do you approach a patient with lower risk stage III colon cancer who is unable to tolerate the planned 3 months of oxaliplatin-based therapy due to neuropathy?

For a stage III patient, I would favor dropping oxaliplatin and just continuing 5FU/leucovorin for the final 3 months (total of 6 mo of treatment). As this is early to see this degree of neuropathy, consider screening for other contributing causes, such as B12 deficiency or diabetes. If this patient...