How do you work up patients with low level monoclonal lymphocytosis and adenopathy?

In the setting where the blood has a CLL-like clone but does not meet criteria for CLL, I would obtain a lymph node biopsy to confirm the diagnosis of SLL. Although this is most likely to be the case, MBL clones can be seen in the blood concomitantly with other cancers as well.

Interesting question. I can only see one benefit of a biopsy at that stage, and it would be to r/o a concurrent process, as finalizing a diagnosis of CLL or SLL wouldn’t change the management strategy in what one can assume is an asymptomatic patient.

Asymptomatic patients who have MBL (<5 x 10⁹/L malignant B-cells in blood) and associated lymph node disease that is palpable have the diagnosis of CLL/SLL. If they are asymptomatic, I do not scan these individuals or biopsy the palpable lymph node.

My approach here would be to:

1. Initiate prognostic...

I would consider a biopsy of an enlarged node, depending on the characteristics of the node, independent of the monoclonal B-cell lymphocytosis.

Depends on the clinical context, patient is symptomatic or note, and the size and distribution of lymph nodes. Patients with MBL can have other concomitant malignancies.