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How do you approach a patient with stage IIA non-small cell lung cancer who received SBRT?

Would you offer chemotherapy after radiation is completed?
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What adjuvant therapy, if any, do you offer a patient with stage IIA NSCLC who received SBRT?

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3 Answers
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Medical Oncology · Albert Einstein College of Medicine at Montefiore Medical Center
Answered on · Updated on

Well, this is a very challenging question that certainly has come up in discussions at times over the years and I could conclude with a very simple answer: No or could offer a more twisted answer arriving at the same response- just for the fun of it, let’s do the latter.

So how would we, as a multidi...

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Medical Oncology · University of Illinois College of Medicine at Chicago
Answered on

I agree this is definitely a challenge in the field. Obviously, the main issue is the 25-35% of patients who recur in this setting. This highlights the need for the development of validated biomarkers in this space.

I will highlight one recent small study by Lebow et al., PMID 37795442 in which they ...

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Radiation Oncology · UCLA | VA Greater Los Angeles Healthcare System
Answered on

Most of these patients are cured with SBRT. Therefore, off-label adjuvant therapy has medical, ethical, and medical-legal risks. Choose wisely.

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