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Topics:
Pediatric Hematology/Oncology • Sarcoma • Medical Oncology • Ewing Sarcoma • Pediatric Oncology
How do you approach adjuvant therapy for resected Stage I Ewing sarcoma of the kidney?
What chemotherapy regimen and cycle duration do you recommend
Answer from: Medical Oncologist at Academic Institution
From a chemotherapy standpoint, all stages of Ewing Sarcomas are approached the same way. There are differences in surgical approach between localized disease versus metastatic disease. We give VAC alternating with IE for six cycles, each. Since this is resected, this regimen should be given in the ...
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Answer from: Medical Oncologist at Academic Institution
The general consensus would be to treat with SOC systemic therapy. This typically is the alternative VAC/IE regimen (or VAI for some) with the caveat that renal function needs to be acceptable, especially if the patient has already had a nephrectomy. The duration answer may differ a bit between pedi...
Answer from: at Community Practice
Agree with VDC/IE to start with and monitor electrolytes/renal function. Pediatric protocols use 14 cycles, but there is a high risk of Fanconi syndrome with a single kidney (assuming the patient had a nephrectomy for resection). The COG AEWS1031 protocol allowed the use of C/E - cyclophosphamide/et...