How do you approach adjuvant therapy for resected Stage I Ewing sarcoma of the kidney?

From a chemotherapy standpoint, all stages of Ewing Sarcomas are approached the same way. There are differences in surgical approach between localized disease versus metastatic disease. We give VAC alternating with IE for six cycles, each. Since this is resected, this regimen should be given in the ...

The general consensus would be to treat with SOC systemic therapy. This typically is the alternative VAC/IE regimen (or VAI for some) with the caveat that renal function needs to be acceptable, especially if the patient has already had a nephrectomy. The duration answer may differ a bit between pedi...

Agree with VDC/IE to start with and monitor electrolytes/renal function. Pediatric protocols use 14 cycles, but there is a high risk of Fanconi syndrome with a single kidney (assuming the patient had a nephrectomy for resection). The COG AEWS1031 protocol allowed the use of C/E - cyclophosphamide/et...

Since the intent is cure, treat it with "adjuvant" systemic therapy like a standard Ewing sarcoma, until maximum tolerance.