How do you approach adjuvant treatment of non-uterine leiomyosarcoma?

Topics: Gynecologic Cancers • Sarcoma • Medical Oncology

When, if ever, do you utilize adjuvant RT or chemotherapy?

Answer from: Medical Oncologist at Academic Institution

I approach non-uterine LMS the same way I approach other soft-tissue sarcomas. Radiation is utilized if margins are close. In the extremity the hope is for 2cm of margins, but at least 1 cm. Anything less than that should get radiation to improve local control (Bean et al 2014). In the retroperitone...

Comments

Medical Oncologist at Oregon Health & Science University
I agree, except to comment that chemotherapy is ge...

Medical Oncologist at Ventura County Medical Center
How would recurrent oligometastatic disease,follow...

Medical Oncologist at Emory University
I would watch for the next focus of oligometastati...

Answer from: Medical Oncologist at Academic Institution

I do not offer adjuvant chemotherapy to persons with leiomyosarcoma. One can make a case that the large negative randomized study EORTC 62931 published in 2012 supplants the 2008 meta-analysis of smaller studies that showed survival benefit from adjuvant chemo. Adjuvant chemotherapy with ...

Related Questions