How do you approach an isolated CNS relapse of AML in a young child under the age of 5?

Isolated CNS relapse in pediatric AML is a rare event. Relapses are usually in the bone marrow +/- CNS involvement, suggesting that AML is a systemic disease in need of systemic therapy. Having said that, there is evidence that local treatment with intrathecal (IT) therapy can be effective in an iso...