How do you approach antidepressant selection in patients with prolonged QTc?

In 2018, the American Psychiatric Association published a resource document on "QTc Prolongation and Psychotropic Medications," which was later followed up by a 2020 American Journal of Psychiatry publication:

These manuscripts highlighted a few key points when making clinical decisions related to Q...

Based on a large-scale review (Pillinger et al., PMID 41135546), the only antidepressants that tended (not statistically significant) to increase QT interval in the general population of depressed patients were doxepine, nortriptyline, and amitriptyline.