How do you approach autologous stem cell transplant in T-cell lymphomas/PTCL after induction chemotherapy with achievement of CR1?
NCCN says "consider autologous HCT" while retrospective data seems to support SCT in most histologies like AITL
1 Answer
Mednet MemberInvited Expert
Hematology · UMass Chan Medical School
Answered on
Autologous SCT can be considered in PTCL in CR1 especially if the patient is MRD negative by PET and molecular testing (by checking for the persistence of clonal T cells, for example). Schmitz et al., PMID 33512419
If MRD positive CR or PR/SD, would consider allogeneic SCT instead. The main concern ...
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