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Breast Cancer • Medical Oncology
How do you approach first line therapy for metastatic, hormone receptor positive, HER2 negative breast cancer in post menopausal women?
Based on results from PALOMA1 and recently reported MONALEESA2, do you use a CDK4/6 inhibitor as initial therapy? In what circumstances would you use anti-estrogen therapy alone?
Answer from: Medical Oncologist at Academic Institution
I use palbociclib and letrozle in the vast majority of women who come to me with de novo ER positive MBC. If a woman recurs with ER positive MBC while on an AI, I use faslodex and palbociclib. Ribociclib also has shown benefit in the recently completed phase III (MONALESSA2) trial, but it is not yet...
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