New: NCI-funded clinical trial search
Mednet Logo

How do you approach initial treatment for AL amyloidosis with excess plasmacytosis in the bone marrow, that has cardiac involvement and is not a transplant candidate?

Let's assume they have cardiac involvement and transplant may not be feasible.
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Washington, Fred Hutchinson Cancer Research Center
Answered on

This is the mirror image of an earlier question on theMednet, namely how we would approach MM treatment in someone who was incidentally diagnosed with AL amyloidosis:

https://www.themednet.org/question/13482

Here, it's how we would approach AL amyloidosis with someone well over 10% bone marrow plasma cells - I'll assume this question is assuming to a scenario like ~50% BMPCs so not myeloma-defining its own right.

In brief, I'd suggest treating this as standard amyloidosis with Dara-CyBorD and plann...

Join for free or sign in to see the full answer