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How do you approach less common cutaneous/mucosal toxicities from EGFR TKI and monoclonal antibody therapies, such as ocular (keratitis and conjunctivitis) and genital mucositis (vulvovaginitis and balanitis)?

1 Answer
Mednet Member
Medical Oncology · Iowa Cancer Specialists, PC
Answered on

I have a patient with metastatic colon ca who was on pembrolizumab for ~16 months with NED who developed grade 3 oral/upper GI mucositis felt to be an autoimmune AE after extensive work-up. He very gradually responded to high dose prednisone followed by a slow taper that took several months due to flares in symptoms. He fully recovered and has remained on observation without resuming IO, is ~12 months on observation and has NED. If ocular symptoms, would of course refer to Ophthalmology but woul...

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