How do you approach management in patients with adult-onset Still’s disease presenting with active polyarthritis (without macrophage activation syndrome) who remain symptomatic despite prednisone 15 mg/day and methotrexate 25 mg/week?
What biologic therapy do you consider next?
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What biologic therapy do you consider next in a patient with adult-onset Still’s disease presenting with active polyarthritis who remains symptomatic despite prednisone 15 mg/day and methotrexate 25 mg/week?
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1 Answer
Mednet MemberInvited Expert
Rheumatology · Massachusetts General Hospital
Answered on · Updated on
Biologics, especially IL-1 but also IL-6 blockers, have been shown to be beneficial for patients with Still's disease. In fact, there seems to be a window of opportunity whereby patients that are started early on cytokine blockade are more likely to achieve drug-free remission in the future. Anakinr...
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