How do you approach management of locally-advanced, unresectable, but non-metastatic bladder cancer?

"Locally advanced" has a broad meaning. I will focus on muscle invasive urothelial carcinoma which is non-metastatic, node negative, and does not invade the pelvic or abdominal wall, and is a maximum of T4a, N0, M0 disease, and in those patients who either have unresectable disease or who are not su...