How do you approach management of sickle cell patients who mistrust Western medicine and prefer naturopathic therapies?

With compassion and understanding, I would explain that the lifespan of patients with SCD in regions with access to Western medicine far exceeds that where the disease is most prevalent. Controlled clinical trials have proven the utility of hydroxyurea to alter beneficially the course of disease and that voxelotor and crizanlizumab worked in a controlled trial; no such proof is available for any naturopathic medication. L-glutamine as single therapy has not been very well accepted. I would use i...