How do you approach MDS patients with low/very low risk IPSS-R but high risk mutations on NGS?

Topics: Hematologic Malignancies • Medical Oncology • Myelodysplastic Syndromes • Hematology

Do next generation sequencing results influence diagnostic and therapeutic decisions for patients with MDS?

Answer from: Medical Oncologist at Community Practice

This a great question and one that I think will become more frequent in clinical practice. As it stands in my practice currently, I have been managing my IPSS-R low/very low-risk patients as I always have, with either observation, ESAs, or lenalidomide (in the case of those with del 5q). Age and com...

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at Northwestern University
Finding high risk mutations in a patient with a di...

Answer from: Medical Oncologist at Community Practice

Indeed, we often forget to distinguish between prognostic (that aim to assess the probability of health outcomes that are yet to occur) vs. predictive (that aim to estimate the probability of treatment effect) models. I believe that one of the leading causes of overRx in the contemporary clinical pr...

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