How do you approach patients with ADPKD who wish to become pregnant?

Since ADPKD is a genetic disorder, with the offspring having a 50% chance of inheriting the gene, genetic counseling is in order so that the parents clearly understand the risks.

As with other pregnant patients, both renal function and blood pressure control are important predictors of maternal and fetal health outcomes; both higher BPs and lower GFRs are associated with risks for preeclampsia, lower fetal birth weight/small for gestational age, and worsened renal function postpartum. (Palma-Reis...