How do you approach patients with locally advanced nasopharyngeal squamous cell carcinoma post induction chemotherapy with gemcitabine/cisplatin and imaging showing mild progression?

Yes. Assuming there is no distant metastatic disease now, I would continue with the plan for locoregional control (curative intent) chemoradiation with RT and cisplatin. This was the schema/regimen used in the most recent several large reported randomized studies from China/Taiwan and has been used ...

I agree with Dr. @Dr. First Last. The patient may have mild progression as a result of the treatment effect. There is no need to give more or a different type of induction therapy. At this point, treatment should begin with a platinum-based regimen, as he has outlined in his response. I may consider...