How do you approach patients with osteosarcoma of the maxilla for neoadjuvant chemotherapy?

The SOC treatment for “jaw” OS is a margin negative surgical resection. If indeed feasible (not always the case), this applies to maxillary tumors. Jaw OS does respond poorly to standard chemotherapy. In our experience, HD Ifosfamide may be a better choice than standard Dox/CDDP. We use this approac...

I am assuming that this is an adult patient. We approach these patients using Doxorubicin-Cisplatin for four cycles, followed by surgery. There is no good prospective data to demonstrate that these patients should be treated the way we approach extremity osteosarcoma. However, good retrospective stu...

Surgery