How do you approach patients with SDH deficient advanced GIST tumor for systemic treatment?

For SDHB mutant GIST (the most common SDH mutation), I try to observe them for as long as possible and resect the enlarging lesions when possible (NF1 and SDH mutant GIST tend to grow slowly compared with their KIT/PDGFR mutant counterparts).

If no surgical resection options are available, the les...