How do you approach Pityriasis rubra pilaris that is retinoid resistant?
Do you have a preference for biologics or phosphodiesterase inhibitors?
Answer from: at Academic Institution
I find most PRPs to respond at best incompletely to retinoids--they are not my first line. Any TNF-alpha or IL-12/23 inhibitor is reasonable to try, and there are no head-to-head trials to my knowledge to endorse one other. Mtx may need to be added. IL-17s likely work too for some patients. Dependin...