How do you approach the management of acute attacks of MOGAD-associated optic neuritis?

Specifically, what do you do if there is minimal improvement with IV steroids and/or IVIG?

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For patients with minimal improvement after high dose IV steroids, what do you typically do next?

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2 Answers

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Neurology · UVA Health

Answered on

If vision loss is severe and has not improved after corticosteroids/IVIG, I would consider plasma exchange (PLEX). Although we do not have controlled studies of PLEX in MOGAD, it is often used for cases of fulminant demyelination in other neuroinflammatory disorders.

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Mednet Member

Neurology · Boulder Medical Center

Answered on

I would likely have PLEX followed by IVIG for maintenance if this is a recurrence.

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