How do you approach the psychiatric symptom management of Huntington’s Disease?

The neuropsychiatric features of Huntington's disease are not as consistent as the motor or cognitive features. Still, they can cause substantial disability, be prominent early in the disease, and even occur as initial features. The majority of Huntington’s disease (HD) mutation carriers experience some psychopathology during their lifetime, varying from irritability to psychosis. Still, the prevalence of particular symptoms differs widely due to diverse study populations in different stages of HD and various assessment methods. The commonest is a personality change. Factor analyses of mental and behavioral symptoms in HD tend to show three factors: an affective/anxiety factor, an executive/social cognitive factor, and a psychosis factor (a...