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How do you approach the use of parathyroid hormone-related protein analog drugs in the setting of prior external beam radiation?

If you avoid parathyroid hormone-related protein analog drugs in patients with prior external beam radiation, what data is this based on?
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Are you willing to use PTH anabolic drugs in patients with prior external beam radiation?

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Rheumatology · U of AZ Phoenix Dept of Orthopaedics
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The concerns about prior external beam radiation are due to the independent increased risk of osteosarcoma associated with external beam radiation. The boxed warning associated with the PTH anabolic drugs WARNS that patients with prior radiation should not receive PTH anabolic drugs. (Note this is n...

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