How do you approach the workup and initial treatment of systemic AL amyloidosis?
Once a tissue biopsy has confirmed light chain amyloid, what additional tests do you perform as part of a standard workup?
In whom should treatment be initiated at diagnosis? Is systemic therapy always the preference, or can local modalities (eg. RT) be considered?
Answer from: Medical Oncologist at Academic Institution
1: Ensure that this is light chain. Mass spectroscopy of the tissue to identify/confirm is very important. Even if a patient has positive serum monoclonal protein or light chain, it does not indicate that this is light chain amyloidosis. I have had patients with MGUS and smoldering myeloma with ATTR...
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