How do you approach the workup for a patient with imaging showing features suggestive of cirrhosis?

It is important to clarify what features of the imaging are resulting in this diagnostic impression.

Liver nodularity without other findings of cirrhosis is non-specific and does not make a diagnosis of cirrhosis. An incidental finding of a nodular liver with normal liver enzymes and normal platelet...

Radiologists use the term cirrhosis for a nodular appearance. It is more definitive if other signs of portal hypertension exist, such as splenomegaly, portosystemic collaterals, or even varices and ascites. Correlation with clinical history and blood work (i.e., platelet count, bilirubin, albumin) c...