How do you approach transaminase elevations with use of allopurinol in gout?
Do you rechallenge with lower dose? What is your tolerance for mild persistent transaminitis?
1 Answer
Mednet MemberInvited Expert
Rheumatology · University of Alabama at Birmingham
Answered on
This is quite rare in my practice of the use of allopurinol. That may be because I discourage NSAID concomitant use in people with gout, given their concomitant hypertension, and NSAID-associated GI, renal, and liver toxicity.
1. If mild transaminitis happens, I would approach it as I do for any patient with any other disease - go through their entire med list, ask them to hold off any/all drugs with possible liver toxicity, go to my drug and make an informed decision, re-do blood test in 1-2 we...
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