New: NCI-funded clinical trial search
Mednet Logo

How do you approach transaminase elevations with use of allopurinol in gout?

Do you rechallenge with lower dose? What is your tolerance for mild persistent transaminitis?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Rheumatology · UAB
Answered on

This is quite rare in my practice of the use of allopurinol. That may be because I discourage NSAID concomitant use in people with gout, given their concomitant hypertension, and NSAID-associated GI, renal, and liver toxicity.

1. If mild transaminitis happens, I would approach it as I do for any pat...

Join for free or sign in to see the full answer