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How do you approach treating neuropathic itch?

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What treatments have you had success with managing neuropathic itch?

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3 Answers
Mednet Member
Mednet MemberInvited Expert
Dermatology · Dermatologists of Central States
Answered on

Localized Neuropathic Pruritus:

Life-changing OTC topical called Dermeleve. Key ingredient is strontium, which interferes with the calcium-dependent receptors and calcium channels that are necessary for itch signaling. Works in about 5 minutes, lasts for about 5 hours. STUNNING EFFICACY. It burns li...

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Mednet Member
Mednet Member
Dermatology · University of Virginia School of Medicine
Answered on

Minor, localized neuropathic itch (postherpetic neuralgia, notalgia paresthetica, etc.) can be treated with local, skin-directed treatments such as topical menthol-based creams or lotions and topical capsaicin. I generally avoid topicals containing tricyclic antidepressants such as topical doxepin o...

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Mednet Member
Mednet Member
Dermatology · Forefront Dermatology
Answered on

For compounded topicals, I really like topical gabapentin, amitriptylline, lidocaine (GAL) for broader areas, or ketamine, amitriptylline, and lidocaine (KAL) for smaller areas given the potential toxicity of ketamine. I get my GAL from Skinmedicinals and my KAL from the Art of Medicine. Both are re...

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