How do you approach treatment in a patient with a solitary plasmacytoma with minimal marrow involvement (< 10% clonal plasma cells)?

Solitary plasmacytoma with minimal bone marrow involvement is a confusing entity as even the name seems somewhat contradictory--it is indicating there is a solitary lesion but at the same time indicating that there is systemic involvement (i.e., bone marrow involvement by clonal plasma cells). It is...

Agree with @Dr. First Last's detailed and helpful explanation above. Use of advanced imaging techniques, if not done initially, and repeat biopsy for patchy disease should be considered.

Our practice is to do whole-body PET CT scans for initial staging (no low-dose whole-body CT protocol available), ...