How do you approach treatment in an infant with metastatic atypical teratoid/rhabdoid tumor (ATRT) of the brain?

The term infants is, sometimes, used to describe children less than 3 years of age in the context of a brain tumor management. Hence, this response will cover the management of a child less than 3 years of age with metastatic ATRT with additional comments on infants less than 1 year of age.

Unfortunately, age and extent of metastasis are one of the most important determinants of treatment outcomes in children with ATRT. Children less than 3 years of age with metastatic disease have extremely poor...