The management philosophy for LGG is radically shifting.  For years, the belief was that these were essentially "incurable", slow-growing tumors, and hence the original debate centered around observation versus resection; the observation camp is now squarely in the minority.  The debate th...

Given RTOG9802 showed OS benefit for RT/chemotherapy vs RT alone, which also included those with age <40 and STR, I would favor adjuvant RT AND chemotherapy (Buckner et al, NEJM 2016). Furthermore, there is this new diagnostic criteria based on CIMPACT-NOW consensus that low grade IDH-wildtype as...

Excellent discussion below.  Given that the early vs. delayed XRT shows improvement in seizure-free survival, I think that earlier XRT is particularly beneficial for patients with seizures or large unresected or partially lesions that are already symptomatic. In my experience these large lesion...

In a young patient with a subtotally resected low grade glioma, I give the options of radiation therapy now vs at the time of symptomatic or imaging progression.  In general, I favour delayed radiation therapy given the results of the European study that showed no change in survival outcomes. &...

As stated above 9802 RT+PCV demonstrated survival advantage over RT alone which took years to see the OS benefit, implying a durable benefit to upfront treatment. So any high risk feature low grade glioma should be considered for adjuvant RT. In terms of molecular factors, several excellent article...