How do you approach your choice of systemic therapy for relapsed/metastatic H&N cancer (failed definitive concurrent chemoRT) not amenable to further locoregional therapies?
Do you have a time threshold for re-challenge with platinum? Of note, Checkmate 141 defined platinum refractory as relapse within 6 months of platinum therapy.
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Michigan Medical School
Answered on
If patients fail CRT with a platinum-based regimen within 6 month of the completion of treatment, I generally give them I/O therapy. If > 6 months, the SOC right now is to treat with a platinum based regimen, i.e. EXTREME regimen or a platinum doublet. I will often give a modified version of EXTREME...
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