How do you balance short-term efficacy against increased low-grade toxicity and quality-of-life considerations for higher single-fraction regimens in recurrent glioma patients?

When considering radiation options for recurrent glioma, in my mind, one size does not fit all. I consider several aspects of the specific patient’s clinical situation:

1. Patient’s prior treatments: time interval, volume, location, and anatomic site, response to prior treatment, response duration from...