How do you clinically and diagnostically distinguish stiff skin syndrome from scleroderma?

They are distinct conditions, with scleroderma primarily manifesting as skin thickness, fibrosis, and Raynaud's, while stiff person syndrome is a neurological condition manifesting as rigidity and with muscle spasms. The latter serologically has anti-GAD antibodies, compared to scleroderma, which ha...

For clarification, I believe the original poster’s question is referring to an entirely different entity, of which I am not very familiar with - other than to acknowledge its existence, called stiff skin syndrome, which is an autosomal dominant true connective tissue (noninflammatory) condition char...

One other disease consideration that one should differentiate is diabetic cheiroarthropathy, or "diabetic stiff hand syndrome." These patients can see decreased extension of the digits (often referred to as "Prayer sign" changes) and thickening of the skin in the digits. This can be present in 50% o...