How do you consider the clinical relevance of elevated serum B12 levels as a marker of underlying hepatic disease?

Elevated B12 levels have shown significant relevance and significance to many underlying conditions, particularly a high correlation with underlying liver disease. About 1 in 5 to 1 in 4 B12 levels >1000 pg/ml had a significant correlation. It is a prognosticator, in my opinion, and the literature supports this. Increased B12 levels correlates to more severe liver disease and increased mortality. Should prompt the evaluation for underlying HCC, cirrhosis, or progressive cirrhosis, metastatic liver disease, acute hepatitis, as well as look for other causes such as hematologic malignancies and even renal disease.