How do you convert between tetrabenazine, deutetrabenazine, or valbenazine for management of tardive dyskinesia?
To ensure equivalent dosing due to insurance or formulary changes.
2 Answers
Mednet MemberInvited Expert
Neurology · VUMC Neurology
Answered on
I think of these medications as much more clinically similar than different, with the main differences relating to patients who are fast metabolizers. Fast metabolizers often respond well to lower doses of deutetrabenazine or valbenazine compared to tetrabenazine.
When converting from one drug to an...
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Mednet MemberInvited Expert
Neurology · University of Miami Miller School of Medicine
Answered on
I am not aware of a standard approach for dose conversion between VMAT inhibitors. In practice, though I have not personally done this, I would likely start the new formulation at its standard starting dose and titrate up based on tolerability. The efficacy and side effect profiles can be different,...
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