How do you counsel cluster headache patients interested in treatment via N,N-dimethyltryptamine (DMT) and psychadelics?

My opinion is that the efficacy and safety of psychedelics in the treatment of cluster headache disorder are not fully known.

Per the review article by Im and Sandoe, PMID 40782223, there is some data that comes from case reports, small open-label studies, 1 very small RTC (10 patients) showing some ...