How do you counsel patients and caregivers about the trajectory of cognitive decline in Parkinson’s disease?
I address the subject of cognitive impairment fairly early in PD, since patients may notice mild deficits in multitasking and attention even within the first few years of diagnosis. Strategies such as making lists and breaking down individual tasks are effective in preserving independence. Worsening...
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As part of the overall discussion of nonmotor features, I present cognitive decline as an expected feature of PD. Internally, I anticipate GBA patients, those with dysautonomia early on, PIGD phenotypes, and those exquisitely sensitive to levodopa side effects (sedation, hallucinations early and at ...
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My opinion is that the trajectory of cognitive decline in PD is highly variable and overlaps substantially with normal aging. One of the big problems with observational studies addressing this subject is that recall and selection bias cloud data integrity. Trying to obtain quality data on cognitive ...
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