It appears you are referring to a situation where the uninvolved light chain is quite suppressed and the potentially involved light chain is normal, generating an abnormal ratio. There are other situations such as in CKD where both kappa and lambda light chains will be elevated but the ratio will be...

Typically, one would reassure patients that a single lab value of this nature needs to be taken with a grain of salt and followed over time, especially if they do not have an established diagnosis of a plasma cell disorder. Many times, such abnormalities can be seen with chronic inflammatory conditi...