How do you counsel patients when they ask whether the SSRI or SNRI antidepressant you have recommended will result in weight gain?

This recent study on antidepressant-associated weight gain has generated a lot of interest and press, and can be a helpful starting point: Petimar et al., PMID 38950403.

As with all studies, it has its limitations, but highlights that many people will experience minimal-modest weight change on antide...

Bupropion doesn't cause weight gain, fatigue, or apathy. A lot of people in the past failed a trial of bupropion because, back then, it was a twice-daily dosing so many people forgot the second dose. Now that it's once-daily dosing it would be my first choice (plus it's a lot cheaper than the newer ...

I inform patients that antidepressants may or may not cause weight gain. If it turns out that the one that's prescribed for them does this, then (I tell them) it is not acceptable, and I will prescribe a medicine to counteract weight gain, or we will switch to another antidepressant.

I agree that b...