How do you define treatment-resistant depression in your practice?

What strategies do you use to counsel patients on continuing an antidepressant until therapeutic doses versus switching agents if they perceive a lack of, or incomplete, benefit?

Answer from: at Academic Institution

Well, technically, treatment-resistant depression is defined as no meaningful response after at least two trials of antidepressants at therapeutic doses and durations (≥8 weeks). The first step is to rule out inadequate dosing (try to reach the max dose), poor adherence, and medical comorbidities...

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at Providence Health & Services - Oregon/St Vincent Hospital and Medical Center
Thank you for your answer! Regarding the STAR*D tr...

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How do you define treatment-resistant depression in your practice?

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