How do you define treatment-resistant depression in your practice?
What strategies do you use to counsel patients on continuing an antidepressant until therapeutic doses versus switching agents if they perceive a lack of, or incomplete, benefit?
1 Answer
Mednet MemberInvited Expert
Primary Care · University of Colorado
Answered on
Well, technically, treatment-resistant depression is defined as no meaningful response after at least two trials of antidepressants at therapeutic doses and durations (≥8 weeks). The first step is to rule out inadequate dosing (try to reach the max dose), poor adherence, and medical comorbidities th...
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