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Primary Care • General Primary Care
How do you define treatment-resistant depression in your practice?
What strategies do you use to counsel patients on continuing an antidepressant until therapeutic doses versus switching agents if they perceive a lack of, or incomplete, benefit?
Answer from: at Academic Institution
Well, technically, treatment-resistant depression is defined as no meaningful response after at least two trials of antidepressants at therapeutic doses and durations (≥8 weeks). First step is to rule out inadequate dosing (try to reach max dose), poor adherence, medical comorbidities that could b...
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